ICEERS

The effects of Ayahuasca in humans are not completely investigated, underscoring the need for more clinical research and follow-up studies. The scientific evidence that has been currently accumulated indicates that the use of Ayahuasca by healthy individuals is relatively safe- from a physiological and mental health perspective. Nevertheless, it must be considered that there are no clinical studies regarding the safety profile of Ayahuasca in those suffering from health problems. For example, the effect of Ayahuasca on the cardiovascular system is shown to be moderate in young, healthy individuals, but older people or those with heart problems may experience a different reaction. In these cases, caution is highly recommended. 

Ayahuasca alkaloids interact with the serotonergic system in different ways: beta-carbolines, like Harmine, are inhibitors of the enzyme MAO, which is involved in the degradation of serotonin, among other neurotransmitters. For this reason, the consumption of Ayahuasca with serotonergic drugs, like several other antidepressants, may potentially produce adverse reactions, such as the “serotonin syndrome”, which can theoretically have serious health consequences. Although the possibility of this type of adverse effect is not fully studied, it would be advisable that people under treatment with any drug (including herbal products), or under the effects of any drug which acts on the serotonergic system, exercise caution when considering Ayahuasca consumption.

Another aspect related to Ayahuasca pharmacology is the consumption of beverages and foods rich in Tyramine. This substance is present in beverages such as certain types of wines and in various aged foods. The consumption of Ayahuasca with tyramine-rich products could potentially produce a hypertensive crisis. Although there are no cases in the scientific literature reporting Tyramine intoxication related to Ayahuasca use, this potential risk is not fully studied, so caution is advised. 

With all psychoactive substances and plants, there exists a risk of adverse reactions. Although current scientific studies suggests that the association of Ayahuasca with mental disorders is weak, adverse reactions such as psychotic episodes have sporadically occurred. Therefore, people with a predisposition or a history of psychiatric problems, like psychosis or similar disorders, should be careful with Ayahuasca use, as its effects could potentially exacerbate previous symptoms or produce unwanted effects.

For extended information on safety, read the scientific information on this subject.